Can Wegovy make you tired?
Many people ask me, “Can Wegovy make you tired?”. It is an important question because Wegovy (semaglutide) does not just curb appetite. It also changes how the stomach empties and how the body uses energy, which can leave some patients experiencing what we call Wegovy fatigue or Wegovy tiredness.
For most, this medication is very effective for weight loss and can even improve long-term health outcomes. In fact, a recent study reported that Novo Nordisk’s Wegovy cuts heart risk by 57 percent compared to a rival Lilly weight loss drug, which shows that its benefits may extend far beyond weight control. Still, feeling unusually tired can be discouraging, and it is worth understanding why it happens. Still, some people experience what we call “Wegovy fatigue” or “Wegovy tiredness,” and it is worth understanding why this happens.
There are several possible explanations. First, Wegovy slows gastric emptying, which can make you feel fuller longer. While this is a desired effect for weight loss, it may also contribute to lower energy availability early on. Second, the body is adjusting to reduced calorie intake, which can temporarily create feelings of sluggishness. Lastly, side effects such as nausea or gastrointestinal upset may leave you more drained than usual.
How Common Is Fatigue on Wegovy?
Not everyone taking Wegovy feels tired. In the studies I’ve seen, some patients do report Wegovy fatigue, but it is not one of the most common side effects. Nausea, vomiting, and constipation were far more frequently seen. That said, “Wegovy fatigue” can be more noticeable in people who are starting the medication at a higher dose or who make significant dietary changes at the same time.
It is also important to consider other medical factors. For example, fatigue could be a sign of dehydration, inadequate nutrition, or even unrelated medical issues such as thyroid imbalance or anemia. In rarer but serious cases, extreme tiredness may point to underlying heart concerns. Patients with a history of cardiovascular disease should be monitored closely, since Wegovy has been studied not only for weight loss but also for its effects on heart health. While the medication has been shown to lower cardiovascular risk overall, ongoing evaluation is crucial for safety. This is especially true for individuals who may already have heart conditions, including those at risk of “Wegovy heart failure” concerns, where fatigue can be an early symptom.
Tips to Manage Fatigue While Taking Wegovy
When you start taking Wegovy, it’s normal to feel worn out sometimes. A few little changes in how you eat, drink, and move around each day can make a difference in your energy.
- Stay hydrated. Even mild dehydration can make Wegovy fatigue worse, especially if you are also dealing with nausea or a smaller appetite. Drinking water steadily throughout the day can help keep your energy up.
- On Wegovy, you might not feel very hungry. Just try to nibble on something now and then—like a little protein or some fruit—and it can help with the tiredness.
- Move your body gently. You don’t need to push yourself with hard workouts. Even a short walk or some gentle stretching can help you feel more awake and sleep a little better.
- Prioritize good rest. Adjusting to Wegovy can temporarily affect sleep, so keeping a regular sleep schedule and a calming bedtime routine may help reduce Wegovy tiredness.
Pay attention to your body. Keeping a simple log of your symptoms, meals, and activity can help you and your doctor understand what triggers your fatigue. This is especially useful if tiredness seems more than just a normal adjustment to the medication.
When to Talk to Your Doctor
Occasional tiredness is not unusual when beginning any weight loss medication, but persistent or severe fatigue should not be ignored. You should reach out to your doctor if your tiredness comes with shortness of breath, chest pain, or swelling in your legs, as these could be signs of heart strain or heart failure.
- Side effects are making it hard for you to drink enough fluids or eat properly.
- Tiredness is worsening rather than improving after the first few weeks of therapy.
- You have other chronic conditions, such as diabetes or heart disease, where fatigue may signal something more serious.
Wegovy works well for weight loss, and it can also help lower your risk for heart problems compared to some other options. Still, no medication is without side effects, and “Wegovy fatigue” is a real experience for some patients. The key is to recognize when it is part of the body’s adjustment and when it may be a sign of something that requires medical attention.
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