ozempic vs zepboundOzempic vs Zepbound is one of the biggest questions patients are asking in 2025. Both are injectable medications designed to support better health outcomes, but they were developed for different primary purposes. Ozempic has long been trusted for managing type 2 diabetes, while Zepbound is a newer option created specifically for chronic weight management.

Understanding the differences between Ozempic vs Zepbound is important if you’re deciding which treatment is right for you. From how they work in the body, to their FDA approvals, side effects, and overall results, the two medications offer unique benefits. Below, we break down their similarities and differences in a clear side-by-side comparison.

If you’re deciding between the two, here’s a quick breakdown of their key similarities and differences.

Ozempic vs Zepbound Comparison Table

Feature Ozempic Zepbound
Active Ingredient Semaglutide Tirzepatide
FDA Approval Type 2 Diabetes (2017) Chronic Weight Management (2023)
Mechanism of Action GLP-1 receptor agonist Dual GLP-1 & GIP receptor agonist
Dosage Weekly injection, 0.25–2 mg Weekly injection, 2.5–15 mg
Primary Use Lowers blood sugar, modest weight loss Significant weight loss, potential blood sugar support
Average Weight Loss 12–15 lbs in clinical trials Up to 25% of body weight in trials
Side Effects Nausea, vomiting, fatigue, diarrhea Similar GI effects, sometimes stronger
Cardiovascular Benefits Proven reduction in heart risk Still under study, but early signs positive
Cost ~$900–$1,000/month ~$1,000+/month (varies by coverage)
Manufacturer Novo Nordisk Eli Lilly

Key Takeaways

  • Ozempic is a proven choice for patients with type 2 diabetes, offering reliable blood sugar control and moderate weight loss.

  • Zepbound is newer and designed specifically for weight management, showing stronger results in weight loss trials.

  • Both have similar side effects, costs, and require weekly injections.

  • Insurance coverage may differ, especially since Zepbound is newer.

Still comparing GLP-1 treatments? Check out our full Ozempic vs Wegovy Comparison Guide or explore our Ozempic products and Zepbound products here at RocketMeds.